Bio-TUNE - Fine tune of cellular behavior: multifunctional materials for medical implants

Bio-TUNE aims to develop innovative multifunctional materials to produce a new generation of medical implants with cell
instructive and antibacterial potential.
In biomaterials science, it is well accepted that implant biointegration with surrounding tissues is a major goal. However,
implant surfaces that facilitate cell adhesion, may also favor colonization of bacterial cells. Infection of biomaterials and
subsequent biofilm formation can be catastrophic and significantly reduce patient quality of life, representing an emerging
concern in healthcare.
On the other hand, research efforts devoted to inhibit bacterial colonization are frequently related to cytotoxic agents or
treatments that do not positively affect host tissues. Hence, ideally, to enhance the long-term success of medical implants,
biomaterial surfaces should reduce bacterial colonization levels without compromising the physiological functions of
eukaryotic cells. Yet, the majority of current approaches tend to only focus on either improving cell adhesion or preventing
bacterial infection but rarely explore a combined effect.
In Bio-TUNE we focus on multifunctional coatings to simultaneously address and mitigate both these problems. Thus, Bio-
TUNE introduces a new mindset and different paradigms in the development of biomaterials to respond to unmet clinical
needs.
Bio-TUNE ambitions to 1) Study and understand the interaction of eukaryotic cells with bacteria at the biophysical and
biomolecular level; 2) To develop cell instructive and antibacterial surfaces via biochemical and topographical approaches;
3) Transfer this technology to medical implants.
We seek to decipher the mechanistic of eukaryotic and bacterial cell competition, generate new selective and multi-potential
coatings and topographically-active patterns, and their technological transfer leading to a generation of advanced biomimetic
materials for tissue regeneration and personalized medicine.

Coordinator: UNIVERSITAT POLITECNICA DE CATALUNYA - SPAIN

Start Date: 2020-01-01 /End Date: 2024-12-31

Info at Cordis: https://cordis.europa.eu/project/id/872869

Acronimo: 
Bio-TUNE
Soggetto finaziatore: 
Unione Europea
Programma di Finanziamento e bando: 
H2020-MSCA-RISE-2019
Numero del progetto/Contratto: 
872869
Responsabile Scientifico: 
Prof. Roberto Spurio
ruolo Unicam: 
partner
Partner: 
Nome: 
UNIVERSITAT POLITECNICA DE CATALUNYA
Tipologia: 
Università
Stato: 
Spain
Ruolo: 
Coordinator
Nome: 
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Tipologia: 
Ente di Ricerca
Stato: 
Germany
Ruolo: 
Partner
Nome: 
UNIVERSITY OF BRISTOL
Tipologia: 
Università
Stato: 
United Kingdom
Ruolo: 
Partner
Nome: 
PROTIP MEDICAL
Tipologia: 
Azienda
Stato: 
France
Ruolo: 
Partner
Nome: 
UNIVERSITY OF GLASGOW
Tipologia: 
Università
Stato: 
United Kingdom
Ruolo: 
Partner
Nome: 
UNIVERSITI SAINS MALAYSIA
Tipologia: 
Università
Stato: 
Malaysia - Third Country
Ruolo: 
Partner
Nome: 
UNIVERSIDAD NACIONAL DE GENERAL SAN MARTIN
Tipologia: 
Università
Stato: 
Argentina - Third Country
Ruolo: 
Partner
Nome: 
GADJAH MADA UNIVERSITY
Tipologia: 
Università
Stato: 
Indonesia - Third Country
Ruolo: 
Partner
Nome: 
UNIVERSIDAD PERUANA de CIENCIAS APLICADAS
Tipologia: 
Università
Stato: 
Perù - Third Country
Ruolo: 
Partner
Tipo di finaziamento: 
Horizon 2020